The levels of WNV E-specific IgG were higher at day 8 post-infection in both WT and BAFFR-/- mice that were immunized and infected compared to uninfected mice evaluated 28 days after WNV E-αCD180 immunization (9.7-fold for WT mice, p = 0.002; 6.3-fold for BAFFR-/- mice, p = 0.0003, Fig 6C, S4A Fig). This evidence concerns the gene TNFRSF13C and infection.