Interestingly, a recent publication that showed decreased dimethylation of lysine in H3 histones (H3K36me2) in cases of SCCHN was associated with damaging NSD1 mutations29, although this study did not identify a prognostic role for NSD1 mutations, consider a possible role for NSD2, or assign prognostic value specifically to tumors of the larynx. This evidence concerns the gene NSD2 and head and neck squamous cell carcinoma.