MYC and neoplasm: CCAT2 is upregulated in CRC tissues particularly in cases of metastatic cancer11, and is highly overexpressed in microsatellite-stable CRC tumors, where it enhances chromosomal instability, tumor invasion and metastasis by enhancing WNT signaling and upregulating MYC and MYC-activated miRNAs (miR-17-5p and miR-20)10.