Therefore, we aimed to investigate the association of rs6983267 at 8q24 and HULC rs7763881 SNPs with the susceptibility of CRC as well as adenomatous polyps (AP), the commonest premalignant lesions for CRC, their relationship with clinicopathological data, and their correlation with serum CCAT2 and HULC expression. This evidence concerns the gene CCAT2 and colorectal carcinoma.