CACNA2D1 and open-angle glaucoma: A total of 1520 SNPs in the human genomic region that includes CACNA2D1 (chromosome 7:81.9–82.4 Mb) were evaluated, identifying nominal association for POAG (P < 0.05) for 44 SNPs (Supplementary Table 3), with the lead SNP (rs2299184 [A], P = 0.001, odds ratio = 1.15) located in intron 1 near DNaseI hypersensitivity sites annotated by the Encyclopedia of DNA Elements (ENCODE) as active in non-pigmented ciliary epithelium.