JUP and Microcephaly - facio-cardio-skeletal syndrome, Hadziselimovic type: Mutations in junctional plakoglobin (JUP) and desmoplakin (DSP) cause Naxos disease and Carvajal syndrome respectively, two cardiocutaneous syndromes that include symptoms of woolly hair, cardiomyopathy, and palmoplantar keratoderma9.