To assess the effects of restoring CPT1A levels in ccRCC cells, we infected RCC4 and 786-O cells with an adenovirus encoding a constitutively active form of rat CPT1A that is not inhibited by malonyl-CoA (called CPT1AM) and assessed changes to lipid deposition and tumor growth. This evidence concerns the gene CPT1A and nonpapillary renal cell carcinoma.