Therefore, the aim of this study was to evaluate the associations between alcohol intake and the serum lipid profile according to the genotypes of the alcohol-metabolizing enzymes ADH1B (His48Arg) and ALDH2 (Glu504Lys) and their combinations in Japanese men, in order to gain insight into the association between moderate alcohol consumption and the risk of cardiovascular diseases. This evidence concerns the gene ALDH2 and cardiovascular disorder.