Other genes including melanocyte markers Mart-1, Tyrp1 and Mitf (all of which are down-regulated in metastatic versus non-metastatic C8161 melanoma cells), showed that NGF-induced Mart-1:GFP-positive cells aligned with C81-61 expression profiles and RA-induced Mart-1-positive cells aligned with wild-type C8161 cell expression (Fig. 6A). The gene discussed is TYRP1; the disease is melanoma.