Using a Mart-1 reporter plasmid tested in melanoma cells (kind gift from Michihiro Konno, Nagoya University; Song et al., 2009), we generated a lentiviral Mart-1:GFP promoter reporter plasmid and stably infected both C8161 metastatic and C81-61 non-metastatic melanoma cell lines, co-labeled with nuclear localized H2B-mCherry (Fig. 1A). The gene discussed is H2BC21; the disease is melanoma.