Neurodegenerative diseases, including Alzheimer’s disease (AD), Pick’s disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by the presence of hyperphosphorylated tau protein that aggregates and forms neurofibrillary tangles (NFTs) [14]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.