NRG1 and schizophrenia: AKT1 is one of the effectors in the well-established pathway from neuregulin 1 (NRG1-ERBB4-PI3K-AKT1 pathway), where each of these components have genetic polymorphisms that have been linked to schizophrenia (Emamian et al., 2004; Hatzimanolis et al., 2013).