Total serum IgE, elevated during helminth infection mainly due to increased synthesis of polyclonal IgE, has been proposed to inhibit allergic responses.29, 30 However, contrasting evidence links high serum IgE levels to increased expression of IgE receptors on human basophils,31 and we show positive associations between total IgE and SPT reactivity to both cockroach and dust mite. Here, IGHE is linked to helminthiasis.