SLC2A1 and Stroke: The ischaemic and hypoperfused brain tissue increases its energy needs and studies have shown increased glucose uptake into the ischaemia core and penumbra after experimental stroke in rats.49 The glucose transporter GLUT-1 that is expressed on cerebrovascular endothelial cells mediates uptake of glucose and vitamin C into the brain.50 Here expression of GLUT-1 was decreased after three days of high-fat diet in naïve mice brains and stroke led to a further reduction.