So far, the immunogenicity and immunodiagnostic accuracies of AgB1 and AgB2 have been evaluated demonstrating that the AgB2 subunit provided the highest diagnostic sensitivity and specificity.24, 25 However, other studies reported a higher immunogenicity for the AgB1 subunit.26, 42 In line with these results, we found that AgB1 pool induced high levels of IL‐4 and a significant difference was found between the patients with CE and the NO‐CE subjects demonstrating that AgB1 is the most immunogenic AgB protein in our whole‐blood assay. The gene discussed is IL4; the disease is cholesteryl ester measurement.