PHIP and metastatic melanoma: PHIP is the most upregulated protein in metastatic melanoma and has potential as a therapeutic target and diagnostic marker.66 PHIP(2) has been predicted to be highly druggable.28 A high concentration crystallographic fragment was used to identify compounds 23–25 (reference compounds 4, 12 and 11, Fig. 11).67 Although binding of fragments 23–25 is very weak, they show that it is possible to find hits for the atypical Brds.