Whilst screening the probes against a range of cancer cells lines, BI-9564 was found to induce growth inhibition in a number of AML cell lines, with exposure to BI-7273 found to result in partial but significant inhibition of Myc expression in these cells.87 The role of BRD9 in supporting leukemia-maintenance through the SWI/SNF complex and Myc expression has been subsequently confirmed through genetic knockdown studies.88 To confirm the role of Brd binding in this antiproliferative activity, domain-swapped alleles expressing BRD9 with the Brd of another protein were developed. The gene discussed is MYC; the disease is acute myeloid leukemia.