TRIM28 and cancer: MLL is a large protein with many functional domains including a Brd and is one of the most frequently mutated genes in cancer.124 TRIM28 has been associated with regulation of mitophagy125 and HCMV latency.126 Neither of these Brds has any reported inhibitors despite their interesting links to disease, presumably due to the challenge in finding hit compounds for their atypical KAc binding residues (Asp in MLL and Thr in TRIM28).