BPTF (Bromodomain and PHD Finger Transcription Factor/FALZ) has been linked to various cancers including bladder,36 colorectal,37 melanoma,38 and leukemia.39 BPTF has been predicted to be a highly druggable target.28 Until recently no known inhibitors of BPTF had been available to interrogate its role in the onset and progression of cancer. Here, BPTF is linked to leukemia.