BRPF1 and myeloid leukemia: The bromodomain-PHD finger protein (BRPF) aids the complex assembly of MYST-family histone acetyltransferases (HATs).92 BRPF1 forms a subunit of the monocytic leukemic zinc finger (MOZ) complex in which translocations have been linked to aggressive forms of myeloid leukemia.93 Relatively little is known about the biological function or therapeutic potential of the Brd of BRPF1, however BRPF1B has been predicted to be a highly druggable target.28,94 GSK recently reported the discovery of BRPF1B inhibitor N,N-dimethylbenzimidazolone compound 29 (reference compound 34, Fig. 13).95