Researchers at Genentech demonstrated that SGC-CBP30 and I-CBP112 caused a slowdown in the proliferation of multiple myeloma cells through arrest in the G1 cell cycle phase.10 RNA sequencing of SGC-CBP30 treated LP-1 cells indicated that IRF4 (interferon regulatory factor 4) target genes were down-regulated. This evidence concerns the gene IRF4 and AL amyloidosis.