A family of bromodomain containing proteins, the tripartite motif containing proteins (TRIMs), more specifically TRIM24, TRIM28 and TRIM33, represent interesting targets due to their role in a variety of cancers including breast,116,117 head and neck,118 non-small-cell lung,119 hepatocellular,120 and glioblastoma.121 TRIM24 has been predicted to be difficult in terms of druggability analysis. This evidence concerns the gene TRIM28 and cancer.