Since increased production of IL-1β is known to be important for the clearance of fungal infections and little is known about the contribution of B-lymphocytes to the innate immune fungal defense, we sought to investigate the role of NLRP3 activation in B-lymphocytes upon fungal β-glucan stimulation and compare it with B-lymphocyte responses to CpG. Here, NLRP3 is linked to fungal infectious disease.