PANK2 and Parkinson disease: Neurodegeneration with brain iron accumulation is a genetically heterogenous disorder causing progressive accumulation of iron in the BG and other brain regions, most cases being associated with mutations in PANK2 and PLA2G6. Pantothenate kinase-associated neurodegeneration (PKAN, formerly Hallervorden-Spatz syndrome, #234200) is a recessive disease associated with mutations in PANK2. Patients present with cognitive dysfunction and extrapyramidal features such as parkinsonism and dystonia.