Within this cohort we identified an additional example of an ALS patient carrying an A622G variant in RBM12 and four ALS patients carrying p.S550G/p.S525G/p.S589G (single case) or p.E395K/p.E370K/p.E434K (3 cases) variants in PPARGC1B. This evidence concerns the gene PPARGC1B and amyotrophic lateral sclerosis.