Within this cohort we identified an additional example of an ALS patient carrying a p.D403E mutation in EEF1G, a p.P12R mutation in HNRNPA3, and a p.A297P/p.A308P mutation in SRPK2. This clustering of cases for each of these genes supports the functional significance of the rare variants we have discovered. This evidence concerns the gene SRPK2 and amyotrophic lateral sclerosis.