Thirty-one of the 213 identified RRM-containing proteins in the human proteome rank in the top 250 most prion-like (Alberti et al., 2009; Couthouis et al., 2011); this includes EWSR1, FUS, TAF15, and TDP-43 which are known to be mutated in ALS cases. The gene discussed is EWSR1; the disease is amyotrophic lateral sclerosis.