Up-regulation of IL-6 mRNA in adipose tissue and augmented IL-6 serum levels found in hfd-fed WT mice were blunted in KAP Tg littermates, indicating that KAP beneficial effects preventing hepatic steatosis and IR might be related with its capacity to impair IL-6 production and inactivation of the IL6/gp130 axis in hfd-fed mice. The gene discussed is IL6; the disease is Hepatic steatosis.