As determined by analyzing 11 SN and 48 paired CN and HCC, HULC and MALAT1 expression levels were significantly higher in the CN tissue samples (HULC: median, 0.019 [range, 0.0008 to 0.068]; MALAT1: 0.71 [0.12 to 6.8]; n = 48) than in the SN tissue samples (HULC: 0.0013 [0.0002 to 0.0076], P = 1.7e-06; MALAT1: 0.041 [0.019 to 0.45], P = 1.2e-06; n = 11) (Fig. 1a and b). The gene discussed is MALAT1; the disease is hepatocellular carcinoma.