However, we demonstrated a significant difference between the expression of these two lncRNAs in HCC and other clinicopathological tumor-related factors, indicating that the decreased aggressiveness of HCC may be associated with the expression level of both HULC and MALAT1. Additionally, we demonstrated that the induced HULC and MALAT1 expression in HCC correlates with a better prognosis. The gene discussed is MALAT1; the disease is hepatocellular carcinoma.