Melanoma cell lineage signatures, defined by MITF and AXL scores28, as well as cAMP-signaling associated genes, previously linked to MAPKi resistance in melanoma29, were equally expressed in tumors from patients with and without clinical benefit (Fig. 4d), suggesting that the activity of melanoma cell intrinsic programs does not influence clinical efficacy of ACT. This evidence concerns the gene MITF and melanoma.