This evidence indicates that the pathogenesis of vascular diseases, including atherosclerosis, obese/type 2 diabetic vascular complications and preeclampsia, can be associated with endothelial dysfunction by decreasing eNOS expression via NF-κB activation.2, 3, 10, 12 Therefore, NF-κB plays an important role in inflammation-associated endothelial dysfunction and vascular disorders. The gene discussed is NOS3; the disease is atherosclerosis.