CX3CL1 and hypertensive disorder: In this study, CXCL1 increased more obviously than CX3CL1 in RASMCs subjected to CMS (Fig. 3b and d), whereas Cxcl1, but not Cx3cl1, was increased in hypertension in vivo (Fig. 4 and Supplemental Fig. S1), suggesting that CMS in vitro mimics hypertension in vivo with regard to the expression of CXCL1 and CX3CL1.