Similarly, the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study indicated that although there was no significant association between Lp-PLA2 activity or mass and aortic stenosis progression in the whole cohort, increased Lp-PLA2 activity was associated with a faster stenosis progression rate in the subset of patients with mild aortic stenosis30. The gene discussed is PLA2G7; the disease is aortic stenosis.