Consistent with this lack of association with FPG in Europeans, variants at the SIX3–SIX2 locus were not associated with the T2D risk, FPG, fasting insulin, beta-cell functions, CKD risk, eGFRcrea, eGFRcys, UACR, or microalbuminuria in Europeans (P > 0.05) (Supplementary Tables S6–S9). Here, SIX3 is linked to type 2 diabetes mellitus.