We next interrogated MYC ChIP-seq data from KPC PDA tumor cells28 and found enrichment in MYC DNA binding peaks within 1000 bp of genes which were upregulated in the NEPC gene signature compared to genes upregulated in PCA (Fig. 3c), supporting a role for MYC in regulating the ductal-neuroendocrine lineage plasticity in PDA. This evidence concerns the gene MYC and Patent ductus arteriosus.