In contrast to previous reports using high levels of MYC expression driven by Pdx1-Cre;CAGtTA;TetO-Myc32, two copies of ROSA-driven Myc expressed in the pancreas (ROSAMyc/Myc;Pdx-Cre) alone did not induce tumor formation or affect overall mouse survival (Fig. 3e). Here, PDX1 is linked to neoplasm.