Similarly, we demonstrate here that c-MYC helps to regulate ductal-neuroendocrine plasticity of PDA, where we show that c-MYC bound genes in PDA are enriched in genes specifically upregulated in neuroendocrine-differentiated prostate cancer and that loss of c-MYC in mouse and human PDA cells decreases neuroendocrine marker expression. The gene discussed is MYC; the disease is Familial prostate cancer.