APC and colonic neoplasm: Tamoxifen-induced expression of Pik3caH1047R together with intestine-specific heterozygous deletion of the Apc tumour suppressor gene (Apcflox/+ mice) accelerated colon cancer progression (median survival time of 290 and 134 days in Apcflox/+ and Pik3caH1047R;Apcflox/+ mice, respectively; Supplementary Fig. 4a–c).