Preclinical studies in animal models have similarly demonstrated that complete loss of FKBP51 protects against HFD-induced body weight gain and hepatic steatosis, which is, in part, explained by an increased expression of uncoupling protein 1 (UCP1), a specific marker of browning, in white adipose tissue (WAT) and increased thermogenesis15. This evidence concerns the gene UCP1 and Hepatic steatosis.