The binding of ID1 and c-MYC seemed to have minor negative impact on G6PD transcription.We attribute this positive regulatory effect to ID1-dependant Wnt/β-catenin pathway activation, which directly augments c-MYC expression (Fig. 6e), facilitates more c-MYC protein binding to G6PD promoter, thus enhances G6PD transcription.In fact, the positive regulatory effects of ID1 have been reported in previous studies.In prostate cancer, Zhang et al. [41] described that the binding of ID1 with Cav-1 could activate of Akt pathway and induce Epithelial-Mesenchymal Transition. The gene discussed is AKT1; the disease is prostate carcinoma.