Within the RAS and BRAF wild-type population (n = 153, 14 in RC group and 139 in LC group), OS was still poorer in the RC group than in the LC group (5.7 months vs. 13.2 months, respectively), with marginal significance (p = 0.055, Fig. 2c). This evidence concerns the gene BRAF and laryngotracheoesophageal cleft.