KRAS and laryngotracheoesophageal cleft: Post-hoc analysis of the CALGB 80405 trial, a phase III trial that compared cetuximab and bevacizumab in front-line settings, also showed that cetuximab-treated KRAS exon 2 wild-type patients with RC cancer had markedly poorer survival than those with LC cancer (16.7 months in RC and 36.0 in LC, p < 0.0001) [15].