Further evidence of zinc involvement in Aβ deposition in AD arose from the observation of a significantly reduced plaque load in the brains of Tg2576 transgenic mice (a common mouse model of AD that overexpresses mutant human APP) that were cross-bred with ZnT3 knockout mice, indicating that synaptic zinc does indeed contribute to amyloid deposition in the TG2576 mouse [53]. This evidence concerns the gene APP and Alzheimer disease.