HOTAIR and neoplasm: MVIH suppresses the secretion of phosphoglycerate kinase 1 (PGK1), a protein inhibiting angiogenesis, leading to activation of angiogenesis, which promotes tumor growth and intrahepatic metastasis, whereas the function of HOTAIR on the migration and invasion of HCC cells is associated with decreasing the expression of MMP-9 and vascular endothelial growth factor (VEGF), as well as increasing the expression of RNA binding motif protein 38 (RBM38) [15,37,38].