Over-expression of several lncRNAs, including MALAT1, HOTAIR, H19, and unigene56159, have been demonstrated to increase, while the knocking down of these lncRNAs has been shown to decrease the migration and invasion capacity of HCC cells [12,20,27,32,35,37,42]; the promotion of UCA1 greatly enhanced, while inhibition of this lncRNA significantly reduced, the invasion ability of HCC cells [29], whereas the silencing of HULC or HBx-LINE1 significantly reduced the migration and invasion activity of HCC cells [16,24]. This evidence concerns the gene HOTAIR and hepatocellular carcinoma.