H19 and neoplasm: For instance, HCC cells over-expressing lncRNAs HEIH, HOTAIR, MVIH, HULC, or DBH-AS1 resulted in promoted tumor growth, while HCC cells depleting these lncRNAs resulted in markedly suppressed tumor growth [11,15,17,18,24,25,30,33]; silencing of lncRNAs H19 or UCA1 led to reduced tumor growth [13,28,41], whereas DREH over-expressing HCC cells decreased, while DREH knocking-down HCC cells enhanced, tumor growth when compared with those of tumors formed from control xenografts [43].