SPHK1 and neoplasm: HULC promotes invasion and metastasis by targeting YB-1 and miR-200a-3p, leading to increased expression of MMP-3 and transcription factor ZEB1, respectively; it also sponges miR-107 and enhances the expression of its target gene E2F1, leading to increased expression of sphingosine kinase 1 (SPHK1) and sphingosine-1-phsphate (S1P), which result in enhanced tumor angiogenesis [23,24,25].