AKT1 and hepatocellular carcinoma: H19 reduces the chemosensitivity of HCC cells to doxorubicin by regulating the methylation of the multi-drug resistance 1 (MDR1) promoter and induces its expression, whereas lncRNA MALAT1 could be upregulated in multi-drug resistance (MDR) HCC cells and could then promote autophagy, inhibit apoptosis, and reduce chemosensitivity by sequestering miR-216 and miR-146b-5p and subsequently by activating TRAF6/p-Akt signaling, increasing the expression of anti-apoptotic protein Bcl2 and myeloid cell leukemia-1 (Mcl-1) [36,40,63].