Among them, DREH was downregulated in HBV-related HCC, HBx-transgenic mice, and HBx-expressing mouse liver cells; LET was identified as being decreased in HBV-related HCC, whereas H19 was controversially reported to be decreased in HBV-related HCC while upregulated in HCC [17,19,21,41]. This evidence concerns the gene H19 and hepatocellular carcinoma.