For example, over-expression of lncRNAs UCA1 or DBH-AS1 significantly increased, while knock-down of these lncRNAs greatly inhibited, the proliferation and colony formation of HCC cells [13,18,28,29]; enhanced expression of HULC or HOTAIR promoted, while silencing of these lncRNAs reduced, the proliferation of HCC cells [11,23,24,30,31,32]; siRNA or shRNA against H19, MVIH, HEIH, and MALAT1 successfully inhibited the viability of HCC cells [17,27,33,41], whereas siRNA against DREH, however, enhanced the proliferation effect and colony formation ability of HCC cells [19,43]. This evidence concerns the gene HOTAIR and hepatocellular carcinoma.