For example, miR-122 was found to be frequently downregulated in HBV-related HCC and HBV-expressing hepatic cells, and could not only suppress HBV replication, but also inhibit different aspects of HCC progression by modulating the expression of various target genes, such as cyclin G1, ADAM10, IGF1R, SRF, HMOX1, and PTTG1. This evidence concerns the gene PTTG1 and hepatocellular carcinoma.