In line with this, the PBM-dependent binding of Human adenovirus E4-ORF1 to DLG1 results in the promotion of DLG1 oncogenic functions that contribute to E4-ORF1-mediated phosphatidylinositol-4,5-bisphosphate 3-kinase signaling activation, uncovering unexplored potential tumor activities of DLG1 [33,34]. The gene discussed is DLG1; the disease is neoplasm.