‐Knocking down its encoded receptor impairs migration and invasiveness of RA fibroblast‐like synoviocytes (FLS), which otherwise progress to destroy cartilage and bone. This receptor mediates inflammatory signaling of TGF‐Beta in RA FLS 60.‐ Is a negative regulator of adhesion and invasion of breast cancer cells; its downregulation is associated with worse prognosis 61. This evidence concerns the gene TGFB1 and breast cancer.