Arginine depletion has been shown to induce cell death through a number of different mechanisms, dependent on the cancer subtype.9, 17 Cell cycle analysis of ALL cell lines or patients' blasts showed an increase in cells in G0/G1 (Fig. 5a) and increases in Cyclin B1 and D, compared with untreated cells (Fig. 5b; Supporting Information Fig. S3c). Here, CCNB1 is linked to acute lymphoblastic leukemia.