PEX5L and depressive disorder: These findings identify TRIP8b as a necessary molecule which contributes to EEG desynchronization and TRIP8b deficiency as a likely explanation for thalamocortical dysrhythmia, a perturbation of normal thalamocortical activity that has been observed in various neuropsychiatric disorders including schizophrenia and depression (Llinás et al. 1999; Schulman et al. 2011).