Vegan group showed higher response rate and significant improvement in all variables except CRP. The diet responders have significant improvement in CRP (p < 0.05). Levels of IgG anti-gliadin (p = 0.0183) and anti-β-lactoglobulin (p = 0.0162) levels have significantly reduced from baselines in vegan diet groups. After 6 and 12 months, there was significant increase in Larsen score, number of erosions and joint count in both groupsKey note: Diet change may reduce immunoreactivity to certain food antigens and some RA patients and may have certain clinical benefits. Here, CRP is linked to rheumatoid arthritis.