PCDH8 and pyelonephritis: Compared with O25b-B2-ST131 isolates, O16-B2-ST131 isolates harbored less virulence factors of adhesins (papAH, papC, papEF and papG alleleII).The pap adhesion genes probably played an important role in the pathophysiology of pyelonephritis caused by E. coli [33, 34].