Inflammation-induced increase in the expression of NTPDase2 in intramuscular glia may also contribute to restrain nerve-evoked ACh release in TNBS-induced ileitis due to the activation of ADP-sensitive inhibitory P2Y1 receptors in myenteric nerve terminals (Duarte-Araújo et al., 2009), yet this hypothesis needs further experimental confirmation. This evidence concerns the gene ENTPD2 and Crohn ileitis.