Our findings seem therefore to indicate the absence of an endogenous α7 nAChRs-mediated counter-inflammatory cholinergic tone, similarly to what documented by Di Giovangiulio et al. (2016), who demonstrated that the severity of DSS-induced and T-cell transfer colitis was not increased in α7 nAChR-/- mice. This evidence concerns the gene CHRNA7 and colitis.