Accordingly, the anti-inflammatory properties of various selective α7 nAChR agonists have been demonstrated in a number of models of acute inflammation in vivo, such as acute lung injury (Pinheiro et al., 2017), cardiopulmonary bypass (Ge et al., 2016), burn injury (Kashiwagi et al., 2017), mesenteric and renal ischemia/reperfusion (Li et al., 2013; He et al., 2016), sepsis (Nullens et al., 2016) and post-operative ileus (The et al., 2007). Here, CHRNA7 is linked to Sepsis.