CAT and obesity due to melanocortin 4 receptor deficiency: The observed decreased antioxidant capacity detected in the visceral fat of isolated rats is in line with previous reports describing depletion of antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase in case of adipose tissue dysfunctions and obesity characterized by visceral fat accumulation (Ozata et al., 2002; Fernandez-Sanchez et al., 2011).