Using qRT-PCR and IHC, we demonstrated that the overexpression of BIRC2 (cIAP1) and BIRC3 (cIAP2), both located on 11q22.1-q22.2, was associated with lymph node metastasis in OSCC patients. Here, BIRC2 is linked to metastatic malignant neoplasm in the lymph nodes.