Acquaah-Mensah et al. (2015) reported that RORα expression was abnormal in the hippocampus of patients with Alzheimer’s disease, and that RORα was highly connected in a network of differentially expressed genes, which included genes involved in mitochondrial dynamics such as Fis1 and Opa138. The gene discussed is FIS1; the disease is early-onset autosomal dominant Alzheimer disease.