SPON2 and glomerulosclerosis: In the context of the glomerular filtration barrier, considering the dual role of mindin in cell/matrix adhesion and in inflammation, it is tempting to speculate, similarly to Murakochi and colleagues56, that mindin plays an important role in glomerular disease progression, at the interface between the podocyte maladaptive signalling changes to the actin cytoskeleton and the activation of pro-inflammatory pathways, causing further podocyte damage and ultimately leading to progression of the disease, podocyte loss, and glomerulosclerosis.