The association of Pim-3 with poor prognosis and a stronger capacity for invasion and migration might be explained by the ability of Pim-3 to induce the STAT3 signaling pathway and regulate the expression of apoptosis-related genes and VEGF; these changes trigger the proliferation, differentiation, and apoptosis of cancer cells and genes inhibited the migration and proliferation29. This evidence concerns the gene PIM3 and cancer.