We had earlier identified a unique tumor-derived, 12-chemokine gene expression signature that could accurately predict the degree and type of lymphoid infiltrate, organized remarkably as ELNs that comprise - by immunohistochemistry staining - prominent B cell follicles, T cell marginal zones comprised of both CD4+ and CD8+ cell subsets, and associated follicular dendritic cells23. The gene discussed is CD4; the disease is neoplasm.