To evaluate whether the levels of p-AMPK(Thr172) and p-FoxO3(Ser413) are upregulated in skeletal muscle from cancer cachexia patients, we obtained muscle biopsies from cachectic patients affected by malignancies (colorectal and pancreatic cancers) in which cachexia has a 80% prevalence. Here, FOXO3 is linked to familial pancreatic carcinoma.