Autophagy undergoes both short- and long-term activation during cachexia9,15,28; accordingly autophagy-related transcripts Bnip3, LC3b, GABARAPL1, Atg7, and CathepsinL were considerably increased in vehicle and (−)-JQ1-treated C26-tumor-bearing mice. The gene discussed is GABARAPL1; the disease is neoplasm.