DNER and cancer: To explore the involvement of the BET inhibitor (+)-JQ1 in the activation of catabolic genes and muscle wasting in cancer cachexia, we first established (+)-JQ1 sensitivity in nine cell lines commonly employed in experimental models of cancer cachexia, by assessment of (+)-JQ1 impact on viability after 72 h of (+)-JQ1 treatment, at three different doses (0.1, 0.5, and 1 μM).