(+)-JQ1 administration prevented transcriptional activation of ubiquitin-ligases responsible for skeletal muscle protein degradation, MuRF1 (p < 0.0001, one-way ANOVA), MAFbx/Atrogin1 (p < 0.0001, one-way ANOVA), and Fbxo30/Musa1 (p = 0.0001, one-way ANOVA), which were significantly increased in vehicle and (−)-JQ1-treated tumor-bearing mice compared to the control animal group (Fig. 3c, d; Supplementary Fig. 5b). This evidence concerns the gene TRIM63 and neoplasm.