In TAs of (+)-JQ1-treated tumor-bearing mice, STAT3 activatory phosphorylation (p < 0.0001, one-way ANOVA) and expression of the STAT3 target suppressor of cytokine signaling 3 (SOCS3) (p < 0.0001, one-way ANOVA) were significantly reduced (Fig. 5f). This evidence concerns the gene SOCS3 and neoplasm.