Initial analysis of the family 1 index patient using a targeted Next Generation Sequencing (NGS) gene panel including the SQTS genes, known to be associated with SQTS at that time (CACNA1C, CACNB2, KCNH2, KCNQ1, and KCNJ2, Supplementary Table 2) revealed no pathogenic mutations. This evidence concerns the gene CACNA1C and Familial short QT syndrome.