SBP, DBP, fasting plasma glucose, fasting plasma insulin, HOMA2-IR, TG and TG/HDL-C ratio were significantly higher with weight status shift escalation, regardless of BMI system (all Ptrend < 0.05), whereas HDL-C concentrations were significantly lower from normal weight to obesity (Ptrend < 0.001). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.