CASP1 and influenza: These data suggested that unlike influenza and tuberculosis infection, activity of caspase-1 was not involved in the induction and secretion of IL-36α and IL-36γ by PMs in response to P. aeruginosa. Of note, live P. aeruginosa did not increase activity of caspase-3/7 in either primary PMs or AECs (S2A and S2B Fig).