In agreement with the experiments confirming that ROS can stimulate the NF-kB pathway in adipose precursor cells [27], visASCs from MS subjects cultured for 72 hours under hypoxia showed the highest expression levels of some of the cytokines associated with the senescence-associated secretory phenotype (SASP) (Fig 5A). This evidence concerns the gene NFKB1 and myeloid sarcoma.