NFKB1 and metabolic disease: In line with a possible NF-kB signaling activation by the redox imbalance which underlies metabolic disorders [27; 31], our laboratory has previously revealed increased levels of NFκB in visceral adipose tissue [32] as well as an increased percentage of senescent visASCs from morbidly obese patients [33] and the present study also corroborated alterations in the expression levels of cytokines linked to the SASP.